Martin Stenlo
Despite advancements, lung transplantation remains hampered by both a scarcity of donor organs and by mortality following Primary Graft Dysfunction (PGD). Using lipopolysaccharide, and caused mild to moderate Acute Respiratory Distress Syndrome (ARDS) in 16 donor pigs. Then, Ex Vivo Lung Perfusion (EVLP) and/or extracorporeal hemoperfusion were used to treat the lungs with or without cytokine adsorption. The medication dramatically reduced posttransplant immune cell counts as well as cytokine levels during EVLP. The incidence of PGD was dramatically decreased in treated mice, and histology showed fewer symptoms of lung damage during both treatment periods. Overall, lung transplantation with cytokine adsorption was successful in restoring lung function and lowering PGD.