Ziwei Chen,, Linghan Duan, Oscar Wing Ho Chu, Huitao Wen, Min Chen,*
An idiopathic nodular glomerulosclerosis (ING) patient was admitted to our hospital. In order to further understand ING and its treatment options, we have performed a detailed global screening and analysis of all published ING case reports. Amongst the cases, 55.56% (n=90) of the patients suffered from severe renal impairment, with an average eGFR (epidermal growth factor receptor) of 33.51mL/min/1.73m2 (n=90) and an average creatinine level of 3.22 mg/dL (n=89). Apart from the aforementioned indicators of ING, we have also found that 76.63% (n=107) of the patients were smokers, 93.63% (n=110) were diagnosed with hypertension, 57.52% (n=113) were obese and 45.13% (n=113) of them had dyslipidaemia. We have further identified that within 5 years of hypertension diagnosis, 58% (n=27) of the patients were also diagnosed with ING. Furthermore, 56.75% (n=50) were also found to have extra renal vascular disease. Most importantly, we found that glucocorticoid or immunosuppressant treatments was not effective, or even possibly deteriorate kidney impairment; and a poor control of blood pressure was detrimental to kidneys. Such findings could shed light on the early detection and the development of effective ING treatment.