Ayman Maher Nagib, Ayman Fathi Refaie, Ahmed Ibrahim Akl, Ahmed Hassan Neamatalla, Mohamed Ashraf Fouda1, Mohammed Ade Bakr, Ahmed Abdelrahman Shokeir and Ehab Wahba Wafa
Objectives: Our aim was to identify the diabetic risk profile of new onset diabetes after live donor renal transplantation (NODAT) and its impact on patient and graft survival in Egyptian population.
Patient and methods: A retrospective review of 2019 renal allograft recipients has been performed. Risk factors, medical complications, patient and graft survival were analyzed.
Results: After a mean follow up period of 8.8 ± 5.8 years, 450 (22.2%) recipients developed NODAT. A 455 post transplantation time matched control recipients without DM was selected. Time table revealed that 50% of NODAT cases discovered during the first 6 months post transplantation. The NODAT recipients were significantly older and obese with higher body mass index. Family history of DM was significantly positive among the NODAT group. Cox’s multivariate regression analysis revealed that the older age, positive family history of DM, high BMI, HCV infection and hypercholesterolemia were of significant risk factor. Medical complications were significant in the NODAT group. Patient survival was significantly lower in the NODAT group on the other hand the graft survival was comparable.
Conclusion: NODAT does not statistically affect the graft survival. But, NODAT is a major problem endangers the patient life and must be minded to consider such patient as especially at higher risk for diabetic complications.