Kamarazaman IS, Abdul RL, Nik Hasan MK, Ahmad MR, Ayob MKM, Rahim N and Zakaria N
In this study, the polysaccharide extracts of Pink guava juice (PGJ) and pomace (PGP) were characterised and their antioxidant properties and mitigating effect on expression level of biomolecules involved in early stage of atherosclerosis were investigated. Chemical characterization were performed by HPLC and it was revealed that molar weight of PGJ and PGP by percentage (%) were 63.0:16.2:9.9:6.4:4.2:0.1% of galacturonic acid, xylose, glucose, mannose, galactose and rhamnose, respectively while PGP has 72.6:4.7:2.7:1.3% of galacturonic acid, glucose, galactose and xylose, respectively. PGJ was found to has moderate antioxidant activity whereby PGP has more potent effect at lower concentration. Both PGJ and PGP have the ability to inhibit lipid peroxidation in dose dependent manner. Both also attenuate the tumor necrosis factor (TNF)-α induced ICAM-1 and VCAM-1 expression in dosedependent manner but only PGP could attenuate the MCP-1 expression.